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Tau alzheimer
Alzheimer’s disease (AD) is pathologically defined by extracellular accumulation of amyloid-β (Aβ) peptides generated by the cleavage of amyloid precursor protein (APP), strings of hyperphosphorylated Tau proteins accumulating inside neurons known as neurofibrillary tangles (NFTs) and neuronal loss. Patients with Alzheimer’s disease (AD) present with both extracellular amyloid-β (Aβ) plaques and intracellular tau-containing neurofibrillary tangles in the brain. Nature Reviews Neurology - Interest in tau-targeting strategies for Alzheimer disease is increasing, in part because of the failure of various amyloid-β-targeting treatments in clinical. ” Tau tangles and beta-amyloid plaques — large accumulations of microscopic brain protein fragments that slow a person’s ability to think and remember — are hallmarks of Alzheimer’s disease. Tau research Emerging evidence suggests that Alzheimer’s-related brain changes may result from a. Alzheimer’s…
